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Featured SPR Member
March 2016


EDWARD M. BEHRENS, MD

Edward M. Behrens, MD is the Joseph Lee Hollander Associate Professor in Pediatric Rheumatology at The Perelman School of Medicine at The University of Pennsylvania and Chief, Division of Rheumatology at The Children's Hospital of Philadelphia. He earned his BA from The Johns Hopkins University followed by an MD from The Perelman School of Medicine at The University of Pennsylvania. He subsequently did his residency and fellowship training at The Children's Hospital of Philadelphia after which he joined the faculty there.

Dr. Behrens's research is focused on understanding the pathogenic mechanisms that initiate, propagate, and amplify immune responses in cytokine storm syndromes, with a particular interest in Toll-like Receptor biology. He developed the first animal model of Macrophage Activation Syndrome, which he has used to understand both positive and negative regulators of the disease as well as to investigate the function of the hemophagocyte, a peculiar cell type often found in cytokine storm syndromes. He recently has focused on novel regulators of Hemophagocytic Lymphohistiocytosis, defining a novel role for the cytokine IL-33 in disease pathogenesis and as an attractive therapeutic target. His work has been funded by the NIH, HHMI, and a number of different Foundations. His work has been recognized with a number of awards including the American Society for Clinical Investigation Young Physician-Scientist Award, Histiocyte Society Nezelof Award in Basic Science, and the The Lady Barbara Colyton Prize for Autoimmune Research at the University of Pennsylvania.

View Dr. Behrens' articles in PubMed