Given since 1939, this award honors clinical and laboratory research achievements. Research must be related to pediatrics and published recently, perhaps coming to fruition or attaining recognition during the past few years. Two awards will be presented during the Pediatric Academic Societies' Annual Meeting. Supported by Mead Johnson Nutrition
Associate Professor of Pediatrics and Genetics, and by courtesy, Medicine, Pathology, and Computer Science
Stanford University Stanford, CA
John V. Williams Associate Professor of Pediatrics Associate Professor of Pathology, Microbiology, and Immunology
Monroe Carell Jr. Children’s Hospital at Vanderbilt
Vanderbilt University School of Medicine Nashville, TN
Dr. Butte has shown how to translate hundreds of billions of publicly available molecular, clinical, and epidemiological measurements into novel diagnostics, drugs, and insights into human disease. By intersecting gene expression data on diseases and drugs, Dr. Butte's team has discovered novel receptors associated with type 2 diabetes, that can be targeted with drugs, as well as finding novel uses for existing drug, known as computational drug repositioning. In receiving the White House Champion of Change award in 2013, Dr. Butte has shown the value and potential of publicly-accessible data.
Dr. Williams has advanced the understanding of human metapneumovirus (MPV), a paramyxovirus discovered in 2001, by a) describing the clinical features and epidemiology of MPV in children; b) discovering that RGD-binding integrins serve as receptors for MPV; c) identifying the fusion (F) protein as the sole target of protective antibodies; d) developing candidate vaccines and monoclonal antibodies; and e) finding that MPV and other acute respiratory viral infections cause impairment of lung CD8+ T cells via PD-1 signaling, a pathway previously associated with chronic infections and cancer. Dr. Williams' research has advanced the field in numerous basic and clinical areas.